inherited

How inherited fitness may affect breast cancer risk

 

(THE CONVERSATION) Repeated studies have shown that physical inactivity, and the occurrence of obesity to which it is linked, increases the risk for many chronic diseases, including breast and other cancers.

In fact, the evidence is so compelling that the lifestyle guidelines of most health agencies, both in the United States and abroad, include a recommendation for obesity prevention via maintenance of an appropriate body weight for height and a physically active lifestyle.

However, what if the science behind these recommendations were only about half the story? What if your fitness were influenced not only by your activity level but also by your genes? And, focusing specifically on breast cancer, what if one’s risk of getting breast cancer were influenced by one’s inherited capacity for fitness?

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‘I Inherited a Mess,’ Trump Says, Defending His Performance (LOL….)

WASHINGTON — President Trump on Thursday dismissed reports about his associates’ contacts with Russia last year and vigorously defended his performance in his first four weeks in office, in a contentious news conference that showcased his unconventional and unconstrained presidency.

At a hastily organized White House event — ostensibly to announce a new nominee for labor secretary, R. Alexander Acosta — Mr. Trump engaged in an extended attack on the news media and insisted that his new administration was not a chaotic operation but a “fine-tuned machine.” Any challenges, he said, were not his fault. “To be honest, I inherited a mess,” he said.

In addition to his cabinet announcement, the president revealed that he had asked the Justice Department to investigate government leaks and said he would sign an executive order next week restricting travel to the United States. He promised to produce by March a plan to repeal and replace the Affordable Care Act, followed by another plan to overhaul the tax system.

But his 77-minute news conference was dominated by an extraordinarily raw and angry defense of both his administration and his character. At times abrupt, often rambling, characteristically boastful yet seemingly pained at the portrayals of him, Mr. Trump kept summoning the spirit of his successful campaign after a month of grinding governance to remind his audience, again, that he won.

For a president who has already lost a court battle, fired an acting attorney general and a national security adviser, and lost a cabinet nomination fight, Mr. Trump was eager to demonstrate that he was still in command. He attacked judges for blocking his original travel order and Democrats for obstructing his nominations. He denied being anti-Semitic even when no one accused him of it. With the latest Pew Research Center poll showing that just 39 percent of Americans approve of the job he is doing, Mr. Trump at one point plaintively pleaded for understanding.

“The tone is such hatred,” he said, referring to the commentary about him on cable television. “I’m really not a bad person.”

Mr. Trump disputed any contention that the White House was out of control or not fully functional, and boasted of a flurry of actions intended to create jobs, curb regulations and crack down on illegal immigration.

“There has never been a presidency that has done so much in such a short period of time,” he said. “And we haven’t even started the big work yet. That starts early next week.”

The enactment of a temporary ban on refugees and all visitors from seven predominantly Muslim countries, he maintained, was “perfect,” despite widespread confusion and subsequent court rulings blocking it. “We had a very smooth rollout of the travel ban,” he said. “But we had a bad court.”

Mr. Trump offered his first account of his decision to fire Michael T. Flynn, his national security adviser, for misleading Vice President Mike Pence and others in the White House about the contents of a conversation with Russia’s ambassador in December.

He said he was not bothered that Mr. Flynn had talked with the ambassador about American sanctions on Russia before arriving at the White House. “I didn’t direct him,” he said, “but I would have directed him, because that’s his job.”

The problem, he said, was that Mr. Flynn had told Mr. Pence that sanctions did not come up during the conversation, an assertion belied by a transcript of the call, which had been monitored by American intelligence agencies.

“The thing is he didn’t tell our vice president properly, and then he said he didn’t remember,” Mr. Trump said. “So either way, it wasn’t very satisfactory to me.”

But he said reports that his campaign aides and other associates had contacts with Russia were “a joke” and “fake news put out by the media.” The New York Times reported this week that phone records and intercepted calls showed repeated contacts between some of his associates and Russian intelligence officials in the year before the election.

“Russia is a ruse,” Mr. Trump said. “I have nothing to do with Russia. To the best of my knowledge, no person that I deal with does.”

President Trump’s News Conference: Live Analysis

President Trump is expected to announce a new nominee for secretary of labor. Times reporters will be following live and offering analysis.

However, Mr. Trump said, all the pressure on Russia may ruin any future negotiations with President Vladimir V. Putin. “Putin probably assumes that he can’t make a deal with me anymore because politically, it would be unpopular for a politician to make a deal,” he said.

Like presidents before him, Mr. Trump was peeved at a series of leaks, including about Mr. Flynn’s call and his own conversations with foreign leaders. In addition to requesting the Justice Department investigation, he confirmed that he might assign a New York billionaire, Stephen A. Feinberg, to conduct a broad review of the intelligence agencies. “He’s offered his services, and you know, it’s something we may take advantage of,” Mr. Trump said. But he added that it might not be necessary because “we are going to be able to straighten it out very easily on its own.”

Mr. Trump returned again and again to his contest with Hillary Clinton, replaying key events from the 2016 campaign and reviving his favorite attacks. He repeated a claim that Mrs. Clinton gave Russia access to American nuclear fuel supplies. “I’ve done nothing for Russia,” he said. “Hillary Clinton gave them 20 percent of our uranium.”

The State Department did sign off on the purchase of a Canadian company by a Russian state firm that gave Russia control of one-fifth of America’s uranium production capacity, as did eight other agencies. But Mrs. Clinton was not in a position to approve or reject the deal when she was secretary of state, and it is not known if she was briefed on the matter.

Mr. Trump spent much of the conference berating reporters and their news organizations. Clearly exasperated by coverage of him, he said he did not watch CNN but then gave a detailed critique of one of its shows. He cited specific articles in The Times and The Wall Street Journal that he called “fake,” even harking back to one from last year’s campaign.

“The press is out of control,” he said. “The level of dishonesty is out of control.”

He added later, “The public doesn’t believe you people anymore.”

The acrimony grew so sharp at one point that CNN’s Jim Acosta felt the need to tell Mr. Trump, “Just for the record, we don’t hate you.”

But that did not assuage him. At one point, he called on Jake Turx, an ultra-Orthodox Jewish reporter from Ami Magazine. “Are you a friendly reporter?” he asked.

“I haven’t seen anybody in my community accuse either yourself or anyone on your staff of being anti-Semitic,” Mr. Turx said. But, citing bomb threats against Jewish centers, he said, “What we haven’t really heard being addressed is an uptick in anti-Semitism and how the government is planning to take care of it.”

Mr. Trump bristled, taking it as a suggestion that he was anti-Semitic even though the reporter specifically said the opposite. “I am the least anti-Semitic person that you’ve ever seen in your entire life,” Mr. Trump said.

Mr. Turx protested that he was not suggesting otherwise. “Quiet, quiet, quiet,” Mr. Trump said. “See? He lied. He was going to get up and ask a very straight, simple question.” Instead, Mr. Trump said, the question was “repulsive” and “very insulting.” He later accused Democrats of posing as supporters and holding up signs at his rallies to smear him.

When April Ryan of American Urban Radio Networks asked whether he would meet with the Congressional Black Caucus to discuss his urban agenda, Mr. Trump again seemed piqued.

“Do you want to set up the meeting?” he challenged her. “Are they friends of yours?”

“I’m just a reporter,” said Ms. Ryan, who is African-American.

“Well, then, set up the meeting,” Mr. Trump said.

That exchange and others included claims that were false or disputed. Mr. Trump told Ms. Ryan that he had planned a meeting with Representative Elijah E. Cummings, an African-American Democrat from Maryland, but that Mr. Cummings had said: “It might be bad for me politically. I can’t have that meeting.”

Mr. Cummings later denied that. “I have no idea why President Trump would make up a story about me like he did today,” he said. “I was actually looking forward to meeting with the president about the skyrocketing price of prescription drugs.”

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Similarly, Mr. Trump asserted that his Electoral College victory was the largest since Ronald Reagan’s. But he won fewer Electoral College votes than three of the four presidents since Reagan: Barack Obama, Bill Clinton and George Bush.

When a reporter pointed that out, Mr. Trump brushed it off. “I was given that information,” he said.

Holocaust survivors’ grandchildren call for action over inherited trauma

Jewish activists in Scotland have started a campaign to support the grandchildren of Holocaust survivors across the world, saying the trauma of the extermination camps continues to haunt the descendants of those who suffered there.

Dan Glass, 29, from London, said he heard constant tales of the Holocaust as he grew up, which have deeply affected him into adulthood.

“All four of my grandparents narrowly avoided the gas chambers in Auschwitz and countless of their friends met with this fate. For my father it was a daily conversation in my teens and early 20s and even though I very profoundly understood his pain, one day I had to say to him, ‘Dad, I can’t talk about this anymore.’ My father had a whole wall of books on the subject of the Holocaust – it was all he wanted to talk about, but it was so harrowing for me.”

Glass began speaking to other children and grandchildren of Holocaust survivors, initially for an academic thesis, then later as part of the group he founded Never Ever Again!, a reference to the 1948 Universal Declaration of Human Rights pledge. He said he soon realised he was not alone in being scarred by the traumatic pasts of his relatives.

“I have been privileged to hear so many stories from young people who should now be able to live with joy – but their lives are damaged and they weren’t even there,” he said.

Dan Glass
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Dan Glass (right) with his sister Naomi, grandmother Herti and uncle. Photograph: Dan Glass

Glass adds that other grandchildren of survivors have experienced clinical depression, anxiety, addiction and eating disorders, which they blame on the impact of their families constantly retelling stories of the horrific events their relatives endured.

Ken Feinstein, a second generation family member, whose parents were Holocaust survivors and who grew up in Boston, Lincolnshire, told of how his school teacher, who also survived, insisted children as young as eight watched documentaries on the subject.

“When kids would look away from it she would yell at them, ‘You have no right to do that. I buried my family.’ We must have been about seven or eight years old. How do you prepare children of this age for something like that? They just showed it to us and kind of traumatised us. It was definitely meant to shock us into never forgetting,” said Feinstein.

A young woman from London told Glass of how her grandmother, who was in the Dutch resistance, avoided starvation at times by digging up flower bulbs and sucking out the nutrients. The woman later developed anorexia and believes it was related to the war stories that had been passed down the line and never processed.

Trauma research about the impact of the Holocaust on subsequent generations varies; some studies conclude there is no effect of trauma two generations on, while others claim that breast milk of survivors was affected by stress hormonesthat impacted on the physiology of the next generation. Some in the field of epigenetics say the intergenerational effects of the Holocaust are very pronounced and that the atrocities altered the DNA of victims’ descendants, so that they have different stress hormone profiles to their peers.

Psychologist Ruth Barnett, whose Jewish father fled Germany for Shanghai, narrowly escaping the Holocaust, says she has witnessed inherited trauma in some of her clients.

“Constantly talking about events like the gas chambers to grandchildren is a way that traumatised people try to get rid of it – by sicking it up. But unless it is processed properly, they make even more anxiety for themselves and other generations.”

Never Ever Again! wants to move from what it calls “melancholic memorialisation” to “positive action”, and is calling for mental health provision to treat inherited trauma, as well as campaigning on various issues, including increased surveillance of fascist groups across Europe, supporting the Human Rights Act and challenging anti-immigration legislation.

Glass says that while it is essential to preserve historical facts, the traumatising effect of memory should be addressed now. “Our grandparents went through one horror, but it is important that we learn to process and debrief from their story to bring about wholesale recovery for this generation and the next.

“We should be releasing these old wounds to something beautiful rather than staying paralysed in memory and fear. Until then we cannot properly celebrate their lives or any kind of victory.

“What would our grandparents have felt if they had known we have had to carry their torment through generations? Wouldn’t they have wanted us to find the peace that was robbed from them? Wouldn’t they want us whole and living lives that they lost?

“I realised that if they could speak to us beyond the grave many would have agreed the mourning has to stop and be replaced with something more constructive.”